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Description:Moreover, compared to murine control tissues, EcoMLV was found to be higher expressed not only in PDX independent of the origin of the transplanted human tumor tissue but also in murine cell lines and in CDX. This is in direct contrast to the findings of Zhang et al. Therefore, we also addressed the question, whether mERV expression is transient or more stable in cell cultures from freshly explanted human xenograft tissue with a series of CDX- experiments. The best explanation for this finding is that mERV are expressed in the murine cells present in PDX tissues and thus mERV expression vanishes with the decreasing contaminating murine cells. This result might partly explain the high contamination rate described by Zhang et al.

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