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Description:In other projects Wikimedia Commons Wikinews. This page was last edited on 5 September, at By using this site, you agree to the Terms of Use and Privacy Policy. Signaling cascade in the nucleus accumbens that results in psychostimulant addiction v t e Note: Nuclear pore Nuclear membrane Plasma membrane Ca v Following presynaptic dopamine and glutamate co- release by such psychostimulants, [ 64[ 65 postsynaptic receptors for these neurotransmitters trigger internal signaling events through a cAMP- dependent pathway and a calcium- dependent pathway that ultimately result in increased CREB phosphorylation. Psychostimulant conditioned place preference. Reinstatement of drug- seeking behavior. CREB phosphorylation in the nucleus accumbens. Sensitized dopamine response in the nucleus accumbens.

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